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  • Helmholtz-Zentrum München
  • Frankfurt, Germany

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jdhenaos/README.md

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Integrating bulk and single-cell multi-omics to decode gene regulatory programs in chronic lung disease.

PhD in Computational Biology · Helmholtz Munich  |  Open to postdoctoral & staff scientist positions


Contact

LinkedIn Email Bluesky


About

I am a computational biologist with a PhD from Helmholtz Munich, where I developed methods for multi-omics data integration and gene regulatory network (GRN) inference applied to chronic lung diseases — including bronchopulmonary dysplasia (BPD), asthma, and COPD.

My work spans bulk and single-cell transcriptomics, proteomics, metabolomics, CITE-seq, and scTCR-seq. I contribute to open-source tools in the R/Bioconductor and Python ecosystems, and I care deeply about reproducible, well-documented scientific software.


Skills & Tools

Languages

R Python Bash

Frameworks & Libraries

Bioconductor Seurat Scanpy PyTorch MOFA+

Infrastructure

Docker Linux CUDA Git


Featured Projects

Project Description Stack
omicslog Logging-aware for SummarizedExperiment and AnnData objects for auditable omics workflows R · Python · Bioconductor · scverse
KiMONo Knowledge-guided multi-omics network inference framework R · Multi-omics · GRN
cellNexusPy Unified single-cell data access layer with Python API contributions Python · scRNA-seq
Biocfomo R wrapper for spatial transcriptomics foundation models via basilisk R · GPU · Spatial

Publications

Henao J et al. (2023). Multi-omics regulatory network inference in the presence of missing data. Briefings in Bioinformatics, 24(5), bbad309. → DOI

Henao J et al. (2025). Multi-omic signatures relate to the severity of pulmonary outcome in neonates traced into adult disease. Network and Systems Medicine. → DOI


GitHub Stats

GitHub stats Top languages


Last updated May 2026

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  1. theislab/single-cell-best-practices theislab/single-cell-best-practices Public

    https://www.sc-best-practices.org

    Jupyter Notebook 1.2k 275

  2. cellmapslab/kimono cellmapslab/kimono Public

    KiMONo is a network inference tool for multi-omics datasets. The multi-omics network is calculated by sparse-group-LASSO regression and can incorporate prior biological information using protein-pr…

    R 10 4

  3. tidyomics/omicslog tidyomics/omicslog Public

    Log operations of R omic analyses

    R 2 1

  4. gibbslab/coexnet gibbslab/coexnet Public

    An R package to build CO-EXpression NETworks from Microarray Data

    R 1 1

  5. comp_bio_template comp_bio_template Public template

    Dockerfile 3

  6. MangiolaLaboratory/cellNexusPy MangiolaLaboratory/cellNexusPy Public

    cellNexus: Quality control, annotation, aggregation and analytical layers for the Human Cell Atlas data

    Jupyter Notebook 1